![]() As DHT levels decline, the hair growth cycle becomes more normal, and hair follicles can regain some of their thickness.ĭutasteride is another 5α-reductase inhibitor, but is only approved for the treatment of hair loss in certain countries such as South Korea and Japan. Since 5α-reductase is the enzyme responsible for converting testosterone to DHT, blocking this conversion decreases levels of DHT in the body. (2)įinasteride is a medication known as a 5α-reductase inhibitor, and it works by blocking DHT, the main culprit in AGA. Minoxidil is typically the first treatment option given to patients experiencing androgenic alopecia, and has been a staple in treating hair loss since 1988. Typically it is used as a foam or ointment and used topically on the affected areas of the scalp. Minoxidil (Rogaine®) acts as a vasodilator, expanding the blood vessels underneath the scalp and allowing more oxygen and nutrients to feed the hair follicles. Dutasteride is currently only approved as a pattern hair loss treatment in Japan and South Korea. Minoxidil, finasteride, and LLLT are FDA-approved treatments for androgenic alopecia. Hair loss treatments approved for this condition include minoxidil, finasteride, LLLT, and dutasteride. While the exact mechanism remains unclear, it is thought that increased blood levels of DHT leads to shorter hair growth cycles and thinning of hair over time. DHT is classified as an androgen and is important for male sexual development, but also present in women. DHT is a hormone converted from testosterone by an enzyme called 5α-reductase. It is caused by various factors, one of the most important being a buildup of dihydrotestosterone (DHT). ![]() (1) Hair loss is caused by a number of factors, so treatments for hair loss also vary in their approach.Īndrogenic alopecia, or pattern baldness, is the most common form of hair loss. Hair loss research is important not only for the general appearance and maintenance of hair, but also for a person’s psychological well-being. Hair loss is a condition affecting men and women of all ages, and often comes with significant psychological and social impacts to those affected.
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